Stress urinary incontinence: vaginal microbiota frequently unbalanced

Medication, lifestyle, and hormonal changes during pregnancy are just some of the factors that can disrupt the temperature, humidity, pH, and protective barrier of the vaginal environment. These changes can facilitate the development of pathogenic bacteria and threaten the healthy dominance of Lactobacillus in the vaginal microbiota. This can lead to genital and urological diseases, since the anatomical proximity of the urethra and vagina facilitates close relations between their respective microbiomes.

Incontinence often accompanied by dysbiosis

Is stress urinary incontinence (SUI) part of the growing list of such pathologies? Yes, according to the results of a study ¹ of 32 post-partum patients in a hospital in Hunan province, China, 13 of whom suffered from SUI and 19 of whom did not. While 42.1% of the non-SUI group presented a vaginal dysbiosis, an imbalance in the vagina’s microbial flora, this figure rose to 84.6% for patients with SUI. In other words, vaginal dysbiosis was twice as common – indeed, almost systematic – in the mothers suffering from SUI. Their flora showed an increased relative abundance of Gardnerella, Streptococcus, Prevotella, Dialister, and Veillonella.

An over-connected microbiota?

To unravel the relationships between the various vaginal microorganisms potentially involved in SUI, the researchers carried out what is known as a network co-occurrence analysis of the patients’ microbiota. In other words, they mapped the potential links between various bacteria. They found that the vaginal microbiota of the SUI patients was much more interconnected and complex: when the links between the bacteria were mapped, the network of the non-SUI group displayed 96 nodes and 133 edges, compared with 200 nodes and 409 edges for that of the SUI patients. In general, microbial communities with a high degree of interconnectedness are considered less stable and therefore more susceptible to imbalance.